May 10, 2021
Today, I am blessed to have here with me for a THIRD time Dr.
Benjamin Bikman. He is a biomedical scientist, professor, and
expert on insulin resistance.
Dr. Benjamin Bikman studies diabetes and obesity, and much of
what he focuses on is a seemingly obscure condition called insulin
resistance. But it's, in fact, not very obscure at all.
What is insulin resistance? Why did Dr. Benjamin Bikman devote
his career to studying something like this? Well, insulin
resistance is essentially two things. First of all, some cells in
your body aren't responding very well to the hormone insulin.
Second, you have more insulin than you did before, a condition
called hyperinsulinemia.
Dr. Bikman's research focus is to elucidate the molecular
mechanisms that mediate the disruption that causes and accompanies
metabolic disorders, such as obesity, type 2 diabetes, and
dementia. Driven by his academic training (Ph.D. in Bioenergetics
and postdoctoral fellowship with the Duke-National University of
Singapore in metabolic disorders), he is currently exploring the
different roles of insulin and ketones as critical drivers of
metabolic function. He frequently publishes his research in
peer-reviewed journals and presents at international science
meetings.
In this episode, Dr. Bikman starts by telling us about his
journey with social media. In this, he explains his thoughts on why
people are so addicted to hatred. He then describes his new
manuscript about the differences in the hippocampus of Alzheimer's
brains vs. control brains. Next, he discusses sphingolipids,
different types of fat growth, and the importance of our humble
kidneys! Dr. Bikman finishes up by discussing if people perish
purely from diabetes and the link between salt and insulin
sensitivity.
Pre Order Keto Flex: http://www.ketoflexbook.com
--------------------------------------------------------
/ / E P I S O D E S P ON S O R S
PureForm Omega Plant Based Oils (Best Alternative to Fish Oil):
http://www.purelifescience.com
Use ben4 for $4.00 off.
Upgraded Formulas Hair Mineral Deficiency Analysis &
Supplements: http://www.upgradedformulas.com
Use BEN10 at checkout for 10% off your order.
Text me +1 (786) 364-5002
💻 Free
7 Day Keto Kickstart Challenge: http://www.ketokampchallenge.com​
[09:03] Are You Addicted To Hate? Most Humans Struggle
With This
- There are chemical mediators to the emotions that we associate
with hate.
- As much as we want to say we hated something in the heat of the
moment, the feeling is somewhat satisfying.
- It is like we've just sunk our teeth in, and we've made the
kill.
- There's almost an animalistic instinct, a satisfaction that
comes from letting someone know what you think of them and
expressing your anger, hatred, or frustration at them. That is an
addictive state.
[16:00] Differences In the Hippocampus of Alzheimer's
Brains vs. Control Brains
- Bikman explains that in a new study, they were able to obtain
samples of the hippocampus from donors who had passed away both
with and without Alzheimer's disease.
- The hippocampus is the learning memory center of the human
brain.
- When comparing the control brains and the Alzheimer's brains,
they found a profound reduction in almost every gene involved in
glucose metabolism in the Alzheimer's brains.
- However, when looking at ketone metabolism, both the control
and the Alzheimer's brains looked totally normal.
- This is a massive step in Alzheimer's research because it shows
that it is not a plaque disorder as people believe; it is a
metabolic disorder.
[19:20] The Effect of Sphingolipids In The Brain – A
Mystery Solved
- There is a class of fats in our cells called sphingolipids.
They were named after the mysterious sphynx because we didn't know
what they did for so long.
- However, now we know sphingolipids are doing two things.
- The first is causing the hippocampus to become insulin
resistant. Which in turn results in the reduction in
glucose-related genes being expressed.
- The second is sphingolipids directly alter the function of
mitochondria. Mitochondria produce most of the cell's energy, so if
they can't function well, neither can the cell.
[26:34] Hypertrophy vs. Hyperplasia Fat
Growth
- Fat tissue, what we pinch and jiggle, grows in two different
ways.
- Hypertrophy is where the number of fat cells is set, but each
fat cell itself gets bigger.
- That is a finite growth because once the fat cell has reached
the maximum dimension, the fat tissue stops growing.
- An alternative mechanism of growth is hyperplasia, where the
fat cell gets a little big, and then we make another fat cell and
then make another fat cell, and it continues.
- Hyperplasia is essentially limitless fat growth.
- However, that's actually a healthier way to get fat. If you can
grow fat cells through hyperplasia, they stay very insulin
sensitive, and the body stays insulin sensitive.
[34:00] The Humble Kidney: It’s A Tissue That’s In High
Demand!
- Bikman was surprised in his research at how high the metabolic
demand is in the kidney. In fact, he says he's never seen a tissue
with such high demand as the kidney.
- Compared to the heart, which is known to have high metabolic
demand, the kidney blew through oxygen much faster!
- People look at the humble kidney and think that it is just
filtering blood, when in fact, it is doing much more.
- Of course, it also regulates the hormones responding to
insulin. But even further, it is actually what sends the signal
when the body is getting low on oxygen.
[37:58] Three Ways We Can Support Our
Kidneys
- One of the most important ways to keep our kidneys healthy is
to stay hydrated.
- Second, Dr. Bikman emphasizes the importance of learning to
breathe better to increase blood flow through the body.
- One way to do this is by using strategic vasodilation with
brief breath holds from time to time, especially while moving.
- Last, keeping your insulin low is also important for kidney
health.
- If insulin is high, then insulin is forcing aldosterone to be
high. Then aldosterone tells the kidneys to hold onto all this
stuff that we don't want to hold onto.
[42:59] Has Anybody Ever Died From Type Two
Diabetes?
- Diabetes is considered the seventh leading cause of death.
- Type two diabetes is overwhelmingly the most common form of
diabetes.
- For someone to die of purely type two diabetes, the one thing
that might kill someone is a non-ketotic coma.
- This occurs when their glucose levels are so massively high
that they become hypovolemic.
- This means their blood pressure would be so low that they
cannot pump blood to their brain. This can cause them to lose
consciousness and potentially die.
- However, this is extremely uncommon. What usually kills people
with diabetes is other health issues accelerated by diabetes, such
as heart disease or cancers.
[47:18] The Effect Of Salt On Insulin Sensitivity May
Surprise You
- The obvious way salt and insulin sensitivity are related is
that when insulin is up, it pushes aldosterone to be up, which
forces the kidney to hold onto more salt and water.
- More water means higher blood volume, which in turn means
higher pressure, leading to hypertension.
- However, if you restrict salt, the body becomes determined to
hold onto any salt that it can. This makes the body insulin
resistant.
- The body makes itself insulin resistant in this scenario
because it will raise insulin, which will raise aldosterone, making
the body retain salt.
- So, when you think about today's often dietary advice to cut
salt, they are really creating this vicious cycle by exacerbating
the insulin resistance.
AND MUCH MORE!
Resources from this episode:
Pre Order Keto Flex: http://www.ketoflexbook.com
💻 Free
7 Day Keto Kickstart Challenge: http://www.ketokampchallenge.com​
--------------------------------------------------------
/ / E P I S O D E S P ON S O R S
PureForm Omega Plant Based Oils (Best Alternative to Fish Oil):
http://www.purelifescience.com
Use ben4 for $4.00 off.
Upgraded Formulas Hair Mineral Deficiency Analysis &
Supplements: http://www.upgradedformulas.com
Use BEN10 at checkout for 10% off your order.
Text me +1 (786) 364-5002
*Some Links Are Affiliates*
// F O L L O W
â–¸ instagram | @thebenazadi | http://bit.ly/2B1NXKW
â–¸ facebook | /thebenazadi | http://bit.ly/2BVvvW6
â–¸ twitter | @thebenazadi http://bit.ly/2USE0so
â–¸clubhouse | @thebenazadi
Disclaimer: This podcast is for information purposes only.
Statements and views expressed on this podcast are not medical
advice. This podcast including Ben Azadi disclaim responsibility
from any possible adverse effects from the use of information
contained herein. Opinions of guests are their own, and this
podcast does not accept responsibility of statements made by
guests. This podcast does not make any representations or
warranties about guests qualifications or credibility. Individuals
on this podcast may have a direct or non-direct interest in
products or services referred to herein. If you think you have a
medical problem, consult a licensed physician.